GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1853207 | 1 | rs113546720 | chr10:96561988 | C10orf129 | chr10:96953957-96988685:+ | 0.32 | 5.35 | 1.1E-7 | Blood metabolite levels |
| BRCA | cis | rs6951245 | 1 | rs113575110 | chr7:1084394 | ZFAND2A | chr7:1192544-1199855:- | -0.33 | -6.43 | 1.94E-10 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BRCA | cis | rs7200543 | 1 | rs1135999 | chr16:15131962 | C16orf63 | chr16:15959577-15982447:- | 0.13 | 3.55 | 0.000397 | Metabolic traits;Glycerophospholipid levels |
| BRCA | cis | rs7200543 | 1 | rs1136001 | chr16:15131974 | C16orf63 | chr16:15959577-15982447:- | 0.13 | 3.57 | 0.000373 | Metabolic traits;Glycerophospholipid levels |
| BRCA | cis | rs111803315 | 1 | rs113613442 | chr14:59972563 | C14orf149 | chr14:59939406-59951126:- | -0.24 | -3.49 | 0.000507 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs113613442 | chr14:59972563 | JKAMP | chr14:59951161-59972080:+ | 0.33 | 5.73 | 1.28E-8 | Schizophrenia |
| BRCA | cis | rs11750568 | 1 | rs1136377 | chr5:178513141 | ZNF354C | chr5:178487607-178507689:+ | -0.12 | -4.06 | 5.25E-5 | Height |
| BRCA | cis | rs1853207 | 1 | rs113739251 | chr10:96502658 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.5 | 4.85E-8 | Blood metabolite levels |
| BRCA | cis | rs76419734 | 1 | rs113767110 | chr4:106599814 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.47 | 0.000532 | Post bronchodilator FEV1 |
| BRCA | cis | rs12216499 | 1 | rs113770724 | chr6:159370137 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | ANAPC13 | chr3:134196547-134204865:- | 0.42 | 13.98 | 6.36E-41 | Height |
| BRCA | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | CEP63 | chr3:134204575-134293852:+ | 0.14 | 3.67 | 0.000251 | Height |
| BRCA | cis | rs12468226 | 1 | rs113877751 | chr2:203194721 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.47 | 0.000543 | Urate levels |
| BRCA | cis | rs9783347 | 1 | rs1140047 | chr11:18327684 | GTF2H1 | chr11:18343816-18388590:+ | 0.3 | 7.8 | 1.49E-14 | Pancreatic cancer |
| BRCA | cis | rs867186 | 1 | rs114007205 | chr20:33647503 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.85 | 0.000123 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |